Patnaik,S K; Paulose,C S; Srivastava,S K; Manjula,Misra; Singh,A K; Kumar,D(Department of BioTechnology, January , 1976)
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Abstract:
The levels and kinetic properties of arginase of the liver of s vertebrates
: the fish otifg trhinea e)n, ztyhmee b ias thi(gPhteerro ipnu aslls tph.e), 3t hmeasmqumirarles lin(F cuonmampabruilsuosnp teon tnhaantt oi)f tahned p tohiek iglootahter(Cmaspra s(pC.)atalarec sattulad)i,edth. eT fhreo ga c(tRivaintya
greater than that of the frog. The activity ; its activity in the fish is far
in the bat and highest in the goat. in the bat is the same as in other mammals. The Km of the enzyme is lowest
partially purified enzyme of vertebrates. significant difference in the inhibitory effect of glyoxylic acid on the partially purified enzyme of vertebrates.
Gopalapillai,Indulal; Ivan,Gutman; Vijayakumar,Ambat(Department of Mathematics, August 25, 2007)
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Abstract:
The D-eigenvalues of a graph G are the eigenvalues of its distance matrix D, and the
D-energy ED(G) is the sum of the absolute values of its D-eigenvalues. Two graphs are
said to be D-equienergetic if they have the same D-energy. In this note we obtain bounds
for the distance spectral radius and D-energy of graphs of diameter 2. Pairs of equiregular
D-equienergetic graphs of diameter 2, on p = 3t + 1 vertices are also constructed.
Sulaiman,Pyroja; Binoy,Joseph; Paulose,C S(Department of Biotechnology, December 5, 2006)
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Abstract:
In the present study, serotonin 2C (5-HT2c) receptor binding parameters in the brainstem and cerebral cortex were investigated during
liver generation after partial hepatectomy (PH) and N-nitrosodiethylamine (NDEA) induced hepatic neoplasia in male Wistar rats. The
serotonin content increased significantly (p<0.01) in the cerebral cortex after PH and in NDEA induced hepatic neoplasia. Brain stem
serotonin content increased significantly (p<0.05) after PH and (p<0.001) in NDEA induced hepatic neoplasia. The number and affinity of
the 5-HT2c receptors in the crude synaptic membrane preparations of the brain stem showed a significant (p<0.001) increase after PH and in
NDEA induced hepatic neoplasia. The number and affinity of 5-HT2c receptors increased significantly (p<0.001) in NDEA induced hepatic
neoplasia in the crude synaptic membrane preparations of the cerebral cortex. There was a significant (p<0.01) increase in plasma
norepinephrine in PH and (p<0.001) in NDEA induced hepatic neoplasia, indicating sympathetic stimulation. Thus, our results suggest that
during active hepatocyte proliferation 5-HT2c receptor in the brain stem and cerebral cortex are up-regulated which in turn induce hepatocyte
proliferation mediated through sympathetic stimulation.
Paulose, C S; Kanungo, M S(Department of Biotecnology, April 21, 1982)
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Abstract:
The binding of (-)[ 3H ]dihydroalprenolol , an antagonist of norepinephrine , to $-adrenergic receptors
in different regions of the brain of male and female rats of various ages was measured . The binding to the
synaptosomal fraction of corpus striatum , hypothalamus, cerebral cortex, cerebellum and the brainstems
shows a significant decrease in the binding in old rats of both sexes . Only in the female corpus striatal
region, the binding in the adult and the old is the same . In the case of females, the highest binding is seen
in the young. In the male, an increase in binding occurs up to adulthood , after which it declines,
suggesting a definite sex-related difference in the Q-adrenergic receptor.
Jackson,James; Pius S,Padayatti; Thomas,Paul; Paulose,C S(Department of Biotechnology, December 13, 1996)
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Abstract:
In the present study we assessed plasma and platelet
monoamine content using high performance liquid
chromatography (HPLC). The study included 22 subjects
consisting of 12 freshly-detected male diabetic
patients and 10 age and sex-matched healthy controls.
The same parameters were measured in streptozotocin
-induced diabetic rat models consisting of
controls , diabetic and insulin - treated diabetic rats.
The platelet counts were significantly reduced
(P < 0.05) in rat models as well as human diabetic
samples. The plasma norepinephrine (NE) and epinephrine
(EPI) concentrations were significantly increased
(P < 0.05). The platelet showed a significant
increase (P < 0.01) in NE, EPI and serotonin content.
Increase in the plasma and platelet content of neurotransmitters
may be due to increased sympathetic
function, which is an adaptation for the decreased
platelet count observed in our study . The results indicate
that changes in the neurotransmitter content
of the platelet may be a good index to assess the neurotransmitter
status in pathological condition such as
diabetes mellitus.