Microwave dielectric ceramics based on GdTiNb,-,.Ta,O6 and Sml _.,Y,TiTa06 have been prepared by conventional solid state
method . The GdTiTaO6 and SmTiTaO6 have aeschenite structure with positive rr and GdTiNbO6 and YTiTaO6 have euxenite
structure with negative rr. The rr of the ceramics has been tuned by preparing solid solution phases between the aeschynites and
euxenites for a possible zero rr material . It is observed that GdTiNbt_YTa.,O6 undergoes a phase transition from aeschynite to
euxenite when x=0.75 and in Sml-,YxTiTa06 for x= 0.73. The microwave dielectric properties change abruptly near the transition
region . The rr value approaches zero near the phase transition region while the samples have poor sinterability and poor quality
factor . The unloaded quality factor, dielectric constant and the sign of rr of the solid solution phases are found to depend on the
average ionic radius of the rare earth ion in RE ,-5RE',TiTaO6. The boundary of the euxenite-aeschynite phase transition occurs at
an average ( RE) ionic radius of 0.915 A in Sm,_, Y,.TiTaO6 solid solution phases
Sheelu,Varghese; Bake,Shameena; Lakshmy,P S; Biju,M P; Eswar Shankar,P N; Paulose,C S; Oommen,V Oommen(Department of Bio Technology, August 27, 2001)
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Abstract:
The effects of feeding of 6-propyllhiouracil (6-I'fU) and potyunsaturatcd fatty acids (I'UFA) independently and ill
combination and administration (ip) of a single close of Iriiodothyronine (I',) (2.51ig/IOOg body wl) along with feeding of 6-
PTU and PUFA were studied in cal brain. Dopamine (DA), 5-hydroxytryplophan (5-IIl'I'), serolouin (5-Ill), 5-hydioxy indole
acetic acid (5-111AA), norepinephrine (NF) :uul ceinephrinn (I?I'l) contenls were assayed in the hypothalannls and ccrc
bral cortex regions. It was found that 6-P"l'U Iccding resulted in decrease in dopamine, 5-III', 5 II I I' and 5 IIiAA in both
regions. In animals fed wills PUFA followed by adnliuislralion of T,. the I)A level was found normal.
Ponnachan, P T C; Paulose, C S; Panikkar, K R(Department of Biotechnology, April , 1993)
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Abstract:
Alloxan induced animal model was used to evaluate the potential antidiabetic effect of A . marmelose leaf
extract. The diabetic animals were given insulin injection and another group A . marmelose leaf extract orally.
It maintained the weight of the animals near to the control rats but a significant decrease in weight was noted it
diabetic animals without any treatment . The blood elucose level in 'treated animals were near to that of control
ones. Also a significantly increased glucose tolerance was observed in animals orally given the leaf extract
prior to the experiment . A significant decrease in liver glycogen ( 1.24 -.07 s!/ 100 g of wet tissue) was observed
in diabetic rats which was brought to almost the normal level (I.84- . 14 g; 100 g) with Icaf extract treatment.
Blood urea and serum cholesterol increased ( 62.66 - 3.50 and 192.67± 13.64 mg' dl) significantly in alloxxan
diabetic rats . The leaf extract treatment decreased the blood urea and serum . cholesterol (37.83 - 3.97 and
99?0±8.43 mg/dl ) to that of control ones . A similar effect was seen with insulin treatment . The results
indicate that the active principle in .4. marmelose leaf extract has similar hypoglycaemic activity to insulin
treatment.
Simon,Chiu; Paulose,C S; Ram,K Mishra(Department of Bio Technology, July 7, 1980)
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Abstract:
Effect of L-prolyl-cinagta tlheep spyo atenndt idaol paanmti-iPnaer/nkeinusroonleiapnti cp rreocpeeprttoiers b oifn dLi-npgrso.lyPl E-LP-TleIuDcEylS- g2l(y1c)Li n1-a0lem5u-ic1dy1el1-g,(Ply1Lc9iG8n1)a. mw-Taidhsee i nm(vPeeLcstGhiag) anotinesmd n ie onuf rb oaelchetapiovtinico -suuirnbadslu eacrnevddetnarflefetueeacrrtmto
a coephfnp ePtrmLe(2icGc0iaa, lob4 mnl0y io atndnhedevl sii8tn r0oto fem dndgosoi ppktyaag mm o-1fii nn tSeehCr/eng cteiwcau tfiracuolenle edpcptattiiioiclcny r r feienoscrp et ohfpinetvos erer ad ebtali.iyncAsdit)cienusdgit ge bin nyai dfrhimacaatli nonsttpilrseytirar aiatdtuttoimeolnn u(a3aso tmfde PidgfL f hkeGargel -o(n'p2tI0ieaPr ali)ldn.y odB ll ay4-b 0icne omldlneugtdc rk eabgdsy t - c1,aa pcSthoaCrmleo)ponfrsaicypil .heP TidLn hteGoe
pahnidn esp tior odpoepraimdoinl ew raesc aelpstoo ersx ainm tihnee dst.rPiaLtuGm s,elbeuctt ihvaedly n eon ehfafneccte don t h['eH a]ffsipniirtoyp oefr tidhoel sbpiencdifinicg .b Tinhdei nbge hoafv aigouonraislt an[3dH b] iaopcohmemori--
cal results obtained in the present study raise the possibility that PLG may facilitate nigro-striatal dopaminergic neurotransmission
through interacting with a unique PLG receptor functionally coupled to the dopamine receptor cyclase complex. -adenylate
Balarama Kaimal,S; Gireesh,G; Paulose,C S(Department of Biotechnology, January 4, 2007)
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Abstract:
Gamma amino outyric acid is a major
inhibitory neurotrarsr titter in the central nervous
system. In the preset study sv, Have investigate(' the
alteration of GABA receptor, In t he hrain stem of rats
during pancreatic regeneration. Three groups of rats
were used for the study: sham operated, 72 It and
7 days partially pancreatectonnsea. GABA was (juan-
(ified by [H]GABA receptor iispiacement method.
GABA receptor kin: 10, pat at i et•ers were studied by
using the binding of F'.](iAhA as ligand to the Triton
X-100 treated me,i1,;-:mes a1,J displacement with
unlabelled GABA. GhRA,v receptor activity was
studied by using the [` -1 h3cuculline and displacement
with unlabellecV euculline. ;.\13A content significantly
decreased (1' < (1.(101 ) it, 0-e brain stern during
the regeneration of pancreas. 'I hl, high affinity (IAI3A
receptor binding sho?:ed it sigii'f cant decrease in 131„.,\
(P < 11.01) and K,I 1).05) n 72 h and 7 days after
partial pancreatee 'timv. ";:flhicuculline hin(Iing
showed it signih eat, 'le ( r(, :,e in /Jn1,s and K,I
(P < 0.001) in 72 h pa^.rcreaw,, mised rats when compared
with sham wt--tt' as P,n and K,I reversed to
near sham after 7 da,s of pancreatectomv. The results
sugge,) that GAB A throur,r; ('GABA receptors in
brain Atcem has a regulatory uie during active regeneration
of pancreas which will have inunense clinical
significance in the treatment of cliahetcs.