Ponnachan,P T C; Paulose,C S; Panikkar,K R(Department of Biotechnology, 1991)
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Abstract:
Alloxan induced diabetic animal model was
sed to evaluate the potential antidiabetic effect of
ie aqueous leaf extract of Aegle marmelose. Insuinjection
and oral treatment of Aegle marmelose
of extract to the alloxan induced rats maintained
;e animal weight near to the control rats whereas
,,ere was a significant decrease in weight in alloxan
•duced rats. Insulin injection and oral treatment
the leaf extract reversed the decrease of protein
)ntent in all the organs studied except the pancas.
Glucose level was maintained near to the co-
:rol levels in the insulin injected and leaf extract
Bated alloxan diabetic rats. A significant increased
ucose tolerance was observed in animals orally
ven the leaf extract prior to the experiment. The
suits indicate that there is an increased utilization
glucose in the Aegle marmelose leaf extract treed
rats.
Ponnachan, P T C; Paulose, C S; Panikkar, K R(Department of Biotechnology, April , 1993)
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Abstract:
Alloxan induced animal model was used to evaluate the potential antidiabetic effect of A . marmelose leaf
extract. The diabetic animals were given insulin injection and another group A . marmelose leaf extract orally.
It maintained the weight of the animals near to the control rats but a significant decrease in weight was noted it
diabetic animals without any treatment . The blood elucose level in 'treated animals were near to that of control
ones. Also a significantly increased glucose tolerance was observed in animals orally given the leaf extract
prior to the experiment . A significant decrease in liver glycogen ( 1.24 -.07 s!/ 100 g of wet tissue) was observed
in diabetic rats which was brought to almost the normal level (I.84- . 14 g; 100 g) with Icaf extract treatment.
Blood urea and serum cholesterol increased ( 62.66 - 3.50 and 192.67± 13.64 mg' dl) significantly in alloxxan
diabetic rats . The leaf extract treatment decreased the blood urea and serum . cholesterol (37.83 - 3.97 and
99?0±8.43 mg/dl ) to that of control ones . A similar effect was seen with insulin treatment . The results
indicate that the active principle in .4. marmelose leaf extract has similar hypoglycaemic activity to insulin
treatment.
Jackson,James; Pius S,Padayatti; Thomas,Paul; Paulose,C S(Department of Biotechnology, December 13, 1996)
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Abstract:
In the present study we assessed plasma and platelet
monoamine content using high performance liquid
chromatography (HPLC). The study included 22 subjects
consisting of 12 freshly-detected male diabetic
patients and 10 age and sex-matched healthy controls.
The same parameters were measured in streptozotocin
-induced diabetic rat models consisting of
controls , diabetic and insulin - treated diabetic rats.
The platelet counts were significantly reduced
(P < 0.05) in rat models as well as human diabetic
samples. The plasma norepinephrine (NE) and epinephrine
(EPI) concentrations were significantly increased
(P < 0.05). The platelet showed a significant
increase (P < 0.01) in NE, EPI and serotonin content.
Increase in the plasma and platelet content of neurotransmitters
may be due to increased sympathetic
function, which is an adaptation for the decreased
platelet count observed in our study . The results indicate
that changes in the neurotransmitter content
of the platelet may be a good index to assess the neurotransmitter
status in pathological condition such as
diabetes mellitus.
New dielectric ceramics with formula BaTi3Nb4, O„ and Ba6Til4Nbz039 have been prepared and characterized. BaTi3Nba017 was densified to 92% of TD after firing at 1310 oC for 4 h. However, Ba6Ti 1 4Nb2O39 fired under optimized conditions (1260 ` C for 4 h) showed only 85% TD together with secondary phase. The crystal system of both of the compositions is orthorhombic
Stephen,D S; Mathew,T; Jose,K A; Aanandan,C K; Mohanan,P; K G Nair(Department of Electronics, February , 1993)
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Abstract:
Simultaneous elimination of specular reflection and backscattered
power from a plane metallic surface by simulated
corrugated surfaces of constant period and variable strip
width for TM polarisation is reported. This new configuration
offers almost a ten-fold frequency bandwidth compared
with a regularly spaced strip grating of the same size.