Pearl,Augustine; Dr.Girish Kumar, K(Cochin University of Science and Technology, June , 2008)
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Abstract:
The quality of a drug is determined after establishing its authenticity by testing its purity and quality of the pure substance in the drug and its formulations.Ion selective sensors have become one of the most effective and powerful means for analytical scientists in the determination of drug substances and are playing an increasing role in pharmaceutical analysis.ISEs are cost effective,easy to prepare and can be rapidly manipulated . Potentiometric ion selective sensors have been developed for six drugs namely trimethoprim, ketoconazole, lamivudine, domperidon, nimesulide and Lomefloxacin. The sensors fabricated include both PVC membrane sensor as well as carbon paste sensor. A total of sixteen different sensors have been developed. The response parameters of all the sensors have been studied and the sensors were applied to the determination of the drugs in pharmaceutical formulations and also in real samples like urine.
Description:
Department of Applied Chemistry,Cochin University of Science and Technology
Girish Kumar,K; Chowdary, K P R; Devala Rao, G(Indian Journal Of Pharmaceutical Sciences, January 8, 1999)
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Abstract:
Two simple and sensitive spectrophotometric methods (A and B)in the visible region have been developed for the determination of nimesulide in bulk and in dosage forms.Method A is based on the reaction of reduced nimesulide with nitrous acid followed by its coupling with phloroglucinol to yield an yellow colored azo dye with an absorption maximum of 400 nm and method B is based on the reaction of reduced nimesulide with p-dimethylamino benzaldehyde(PDAB) to form an yellow colored chromogen wiht an absorption maximum of 415 nm.When pharmaceutical preparations (Tablets and suspension) were analysed, the results obtained by the proposed methods are in good agreement with the labelled amounts and are comparable with the results obtained by a reported method.recovery in both the method is 98-101 %.
Kumar,K G; Augustine,P; John,S(Department of Applied Chemistry, June 21, 2007)
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Abstract:
A novel electrochemical sensor has been developed for the determination of nimesulide.
The sensor is based on the NIM- molybdophosphoric acid (MPA) as the electroactive
material in PVC matrix in presence of bis(2-ethyl hexyl) phthalate (BEP) as a
plasticizer. The sensor showed a fast, stable, near Nernstian response for 1 × 10-2 –1 ×
10-6 M NIM over the pH range 5 – 8 with a slope 55.6 ±0.5m V/decade and the response
time is < 45 s. Selectivity coefficient data for some common ions show negligible
interferences. The sensor was successfully applied for the determination of NIM in
tablet and the results obtained are in good agreement with those obtained by the official
method.