Pearl,Augustine; Dr.Girish Kumar, K(Cochin University of Science and Technology, June , 2008)
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Abstract:
The quality of a drug is determined after establishing its authenticity by testing its purity and quality of the pure substance in the drug and its formulations.Ion selective sensors have become one of the most effective and powerful means for analytical scientists in the determination of drug substances and are playing an increasing role in pharmaceutical analysis.ISEs are cost effective,easy to prepare and can be rapidly manipulated . Potentiometric ion selective sensors have been developed for six drugs namely trimethoprim, ketoconazole, lamivudine, domperidon, nimesulide and Lomefloxacin. The sensors fabricated include both PVC membrane sensor as well as carbon paste sensor. A total of sixteen different sensors have been developed. The response parameters of all the sensors have been studied and the sensors were applied to the determination of the drugs in pharmaceutical formulations and also in real samples like urine.
Description:
Department of Applied Chemistry,Cochin University of Science and Technology
Girish Kumar,K; Pearl, Augustine; Sareena, John(Springer, August 29, 2009)
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Abstract:
The fabrication and electrochemical response
characteristics of two novel potentiometric sensors for the
selective determination of domperidone (DOM) are described.
The two fabricated sensors incorporate DOM–PTA
(phosphotungstic acid) ion pair as the electroactive material.
The sensors include a PVC membrane sensor and a carbon
paste sensor. The sensors showed a linear, stable, and near
Nernstian slope of 56.5 and 57.8 mV/decade for PVC
membrane and carbon paste sensors, respectively over a
relatively wide range of DOM concentration (1.0 9
10-1–1.0 9 10-5 and 1.0 9 10-1–3.55 9 10-6 M). The
response time of DOM–PTA membrane sensor was less than
25 s and that in the case of carbon paste sensor was less than
20 s.Auseful pH range of 4–6 was obtained for both types of
sensors. A detection limit of 7.36 9 10-5 M was obtained
for PVC membrane sensor and 1.0 9 10-6 M was obtained
for carbon paste sensor. The proposed sensors showed very
good selectivity toDOMin the presence of a large number of
other interfering ions. The analytical application of the
developed sensors in the determination of the drug in pharmaceutical
formulations such as tablets was investigated.
The results obtained are in good agreement with the values
obtained by the standard method. The sensors were also
applied for the determination ofDOMin real samples such as
urine by the standard addition method.
Description:
J Appl Electrochem (2010) 40:65–71
DOI 10.1007/s10800-009-9975-2