Smitha, Mohanlal; Dr. Jayalekshmy, A(National Institute for Interdisciplinary Science and Technology (CSIR), December , 2011)
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Abstract:
The study was planned to investigate the bioactive compounds in Njavara
compared to staple varieties and their bioactivity to substantiate the medicinal
properties. Results of the study on chemical indices, antioxidant activity and antiinflammatory
activity (in vivo) of Njavara black rice bran and rice in comparison with
non-medicinal varieties like Sujatha and Palakkadan Matta rice bran and rice are given. The phytochemical investigation and quantification of Njavara extracts in
comparison with staple varieties are detailed in this study. The last chapter is divided in three sections (A, B and C). Section A comprises the antioxidant activity
by in vitro assays like DPPH, superoxide anion radical and hydrogen peroxide
scavenging activity of the compounds. Also, theoretical studies using DFT were carried
out based on DPPH radical scavenging activity for understanding the radical stability
and mechanism of antioxidant activity. Section B comprises the anti-inflammatory
activity of the identified compounds namely tricin and two flavonolignans in both in
vivo and in vitro models. Section C describes the cytotoxicity of the rare flavonolignans,
tricin 4’-O-(erythro-β-guaiacylglyceryl) ether and tricin 4’-O-(threo-β-guaiacylglyceryl)
ether towards multiple cancer cells belonging to colon, ovarian and breast tumours.