Jinsa, Jacob Mary; Dr.Prathapachandra Kurup,M R(Cochin University Of Science And Technology, September , 2013)
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Abstract:
Thiosemicarbazones have emerged as an important class of ligands
over a period of time, for a variety of reasons, such as variable donor
properties, structural diversity and biological applications. Interesting as
the coordination chemistry may be, the driving force for the study of these
ligands has undoubtedly been their biological properties and the majority
of the 3000 or so publications on thiosemicarbazones since 2000 have
alluded to this feature. Thiosemicarbazones with potential donor atoms in
their structural skeleton fascinate coordination chemists with their versatile
chelating behavior. The thiosemicarbazones of aromatic aldehydes and
ketones form stable chelates with transition metal cations by utilizing both
their sulfur and azomethine nitrogen as donor atoms. They have been
shown to possess a diverse range of biological activities including
anticancer, antitumor, antibacterial, antiviral, antimalarial and antifungal
properties owing to their ability to diffuse through the semipermeable
membrane of the cell lines. The enhanced effect may be attributed to the
increased lipophilicity of the metal complexes compared to the ligand
alone.
Description:
Department of Applied Chemistry, Cochin University of Science and Technology