Emmanuel, Kadudose A; Dr.Sankaranarayanan, K C(Cochin University of Science and Technology, August 9, 1989)
[+]
[-]
Abstract:
This thesis Entitled Socio-Economic Survey of a Specific village.For the purpose of analysis the thesis is divided into nine chapters. The first chapter introduces the subject of study and explains the significance of the study.It also provides the profile of the village. Chapter two deals with the different aspects of agriculture in the village.Chapter three discusses the problems of industrialisation in the Village. Chapter four is on village administration. It elaborates on the services rendered by government machinery in facilitating the development of agriculture and industry in the village.Chapter five explains the ways and means of marketing of village produce, both industrial and agricultural origin. It also explains the relevance of intra village connections in facilitating marketing.Chapter seven provides information regarding the income and expenditure pattern of the village.Chapter eight is on village social life. It explains the social life of the villagers, including religious
Description:
Department of Applied Economics, Cochin
University of Science and Technology
This paper describes certain findings of intonation and intensity study of emotive speech with the minimal use of
signal processing algorithms. This study was based on six basic emotions and the neutral, elicited from 1660 English
utterances obtained from the speech recordings of six Indian women. The correctness of the emotional content was
verified through perceptual listening tests. Marked similarity was noted among pitch contours of like-worded,
positive valence emotions, though no such similarity was observed among the four negative valence emotional
expressions. The intensity patterns were also studied. The results of the study were validated using arbitrary
television recordings for four emotions. The findings are useful to technical researchers, social psychologists and to
the common man interested in the dynamics of vocal expression of emotions
Reena, Murali; Dr David Peter(Cochin University of Science and Technology, February 15, 2016)
[+]
[-]
Abstract:
Post-transcriptional gene silencing by RNA interference is
mediated by small interfering RNA called siRNA. This gene
silencing mechanism can be exploited therapeutically to a wide
variety of disease-associated targets, especially in AIDS,
neurodegenerative diseases, cholesterol and cancer on mice with the
hope of extending these approaches to treat humans. Over the recent
past, a significant amount of work has been undertaken to understand
the gene silencing mediated by exogenous siRNA. The design of
efficient exogenous siRNA sequences is challenging because of many
issues related to siRNA. While designing efficient siRNA, target
mRNAs must be selected such that their corresponding siRNAs are
likely to be efficient against that target and unlikely to accidentally
silence other transcripts due to sequence similarity. So before doing
gene silencing by siRNAs, it is essential to analyze their off-target
effects in addition to their inhibition efficiency against a particular
target. Hence designing exogenous siRNA with good knock-down
efficiency and target specificity is an area of concern to be addressed.
Some methods have been developed already by considering both
inhibition efficiency and off-target possibility of siRNA against agene. Out of these methods, only a few have achieved good inhibition
efficiency, specificity and sensitivity.
The main focus of this thesis is to develop computational
methods to optimize the efficiency of siRNA in terms of “inhibition
capacity and off-target possibility” against target mRNAs with
improved efficacy, which may be useful in the area of gene silencing
and drug design for tumor development. This study aims to
investigate the currently available siRNA prediction approaches and
to devise a better computational approach to tackle the problem of
siRNA efficacy by inhibition capacity and off-target possibility. The
strength and limitations of the available approaches are investigated
and taken into consideration for making improved solution. Thus the
approaches proposed in this study extend some of the good scoring
previous state of the art techniques by incorporating machine learning
and statistical approaches and thermodynamic features like whole
stacking energy to improve the prediction accuracy, inhibition
efficiency, sensitivity and specificity. Here, we propose one Support
Vector Machine (SVM) model, and two Artificial Neural Network
(ANN) models for siRNA efficiency prediction. In SVM model, the
classification property is used to classify whether the siRNA is
efficient or inefficient in silencing a target gene. The first ANNmodel, named siRNA Designer, is used for optimizing the inhibition
efficiency of siRNA against target genes. The second ANN model,
named Optimized siRNA Designer, OpsiD, produces efficient
siRNAs with high inhibition efficiency to degrade target genes with
improved sensitivity-specificity, and identifies the off-target knockdown
possibility of siRNA against non-target genes. The models are
trained and tested against a large data set of siRNA sequences. The
validations are conducted using Pearson Correlation Coefficient,
Mathews Correlation Coefficient, Receiver Operating Characteristic
analysis, Accuracy of prediction, Sensitivity and Specificity.
It is found that the approach, OpsiD, is capable of predicting
the inhibition capacity of siRNA against a target mRNA with
improved results over the state of the art techniques. Also we are able
to understand the influence of whole stacking energy on efficiency of
siRNA. The model is further improved by including the ability to
identify the “off-target possibility” of predicted siRNA on non-target
genes. Thus the proposed model, OpsiD, can predict optimized
siRNA by considering both “inhibition efficiency on target genes and
off-target possibility on non-target genes”, with improved inhibition
efficiency, specificity and sensitivity. Since we have taken efforts to
optimize the siRNA efficacy in terms of “inhibition efficiency and offtarget possibility”, we hope that the risk of “off-target effect” while
doing gene silencing in various bioinformatics fields can be
overcome to a great extent. These findings may provide new insights
into cancer diagnosis, prognosis and therapy by gene silencing. The
approach may be found useful for designing exogenous siRNA for
therapeutic applications and gene silencing techniques in different
areas of bioinformatics.
Jayasankar, M; Dr.Warrier, K G K(National Institute for Interdisciplinary Science and Technology, December , 2009)
[+]
[-]
Abstract:
The thesis entitled "Sol-Gel Alumina Nano Composites for
Functional Applications" investigate sol-gel methods of synthesis of alumina
nanocomposites special reference to alumina-aluminium titanate and alumina-lanthanum
phosphate composites. The functional properties such as thermal
expansion coefficient and thermal shock resistance, machinability of composites as well as thermal protection are highlighted in addition to novel
approach in synthesis of composites.A general introduction of alumina matrix composites materials,
followed by brief coverage of alumina-aluminium titanate and alumina-lanthanum
phosphate composites is highlight of the first chapter. The second
chapter deals with the sol-gel synthesis of aluminium titanate and alumina-aluminium
titanate composite. The synthesis of machinable substrate, based on
alumina and lanthanum phosphate forms the basis of the third chapter. The
fourth chapter describes the sol-gel coating of mullite on SiC substrate for the
possible gas filtration application.
Sankar, Sasidharan; Dr K.G.K Warrier(Cochin University of Science and Technology, January 16, 2015)
[+]
[-]
Abstract:
Lanthanum phosphate is one among the lanthanide family of “Rare Earths” following the periodic table of elements. Known under the generic name, Monazite, the rare earth phosphates have melting points above 1900 °C, high thermal phase stability, low thermal conductivity and thermal expansion coefficient similar to some of the high temperature oxides like alumina and zirconia.
Smitha, Sasidharan; Dr.Warrier, K G K(Cochin University of Science & Technology, July , 2009)
[+]
[-]
Abstract:
The thesis covers a systematic investigation on the synthesis of
silica aerogels and microspheres with tailored porosity, at ambient conditions by
varying the experimental parameters as well as using organic templates.
Organically modified silica-gelatin and silica-chitosan hybrids were developed for
the first time using alkylalkoxysilanes such as MTMS and VTMS. Application of
novel silica-biopolymer antiwetting coatings on different substrates such as glass,
leather and textile is also demonstrated in the thesis.
Sibu,C P; K G K Warrier(CSIR, FACULTY OF SCIENCE, 2004)
[+]
[-]
Abstract:
In the present work Titania bulk powders and coatings were prepared by subjecting titanium isopropoxide solution to a controlled hydrolysis-condensation process. The powders were characterized using techniques such as FTIR for their chemical interactions, TG-DTA for the thermal decomposition features, XRD for the phase assemblage, BET specific surface area analysis for the textural features. The study discusses the preparation methods and the characterization techniques employed and a detailed discussion on the physico-chemical characterization of the prepared systems. The influence of dopants and leaching on the physico-chemical properties as well as their influence on photo activity is also included. The structural/functional coatings of different Titania compositions includes in this study. Coatings on pre-treated glass surfaces with the best compositions prepared showed 90 % transmittance in the visible region.
Rare earth metal ion exchanged (La3+, Ce3+, RE3+) KFAU-Y zeolites were prepared by simple ion-exchange methods and have
been characterized using different physico-chemical techniques. In this paper a novel application of solid acid catalysts in the dehydration/
Beckmann rearrangement of aldoximes; benzaldoxime and 4-methoxybenzaldoxime is reported. Dehydration/Beckmann
rearrangement reactions of benzaldoxime and 4-methoxybenzaldoxime is carried out in a continuous down flow reactor at
473K. 4-Methoxybenzaldoxime gave both Beckmann rearrangement product (4-methoxyphenylformamide) and dehydration product
(4-methoxybenzonitrile) in high overall yields. The difference in behavior of the aldoximes is explained in terms of electronic
effects. The production of benzonitrile was near quantitative under heterogeneous reaction conditions. The optimal protocol allows
nitriles to be synthesized in good yields through the dehydration of aldoximes. Time on stream studies show a fast decline in the
activity of the catalyst due to neutralization of acid sites by the basic reactant and product molecules.
The rising pressure of Population, together with the constantly changing
technologies, and development perspectives, contribute to the ever increasing
volumes of wastes in different forms. The solid and liquid wastes generated in the
urban areas were considered a burden to the society, and hazardous to the
environment. The fact is that the growth of consumerist culture and aimless
throwing of refuse by the people created the outbreak of environmental pollution.
Unhygienic environment and solid waste accumulation coincided with mosquito
breeding which causes, the spread of most epidemics. The rationale behind most of
the diseases is the unhygienic pattern followed by the people both in rural and urban
areas. As an environmental package, the disposal of solid waste from different
sources, such as house holds markets, commercial areas, slaughter houses, hospitals
and industries, therefore assumed crucial importance. So as a part of the theory and
practice, a study on the area, solid waste management of Arppukara Grama
Panchayat of Kottayam district is taken into consideration. The study conducted here
proposes, to examine the quality and quantity of the solid waste generated in the
panchayat and also it's impact on the existing social, economical, environmental and
ecological systems
Description:
Journal of Global Economy,
Volume 6 No 1, JANUARY-FEBRUARY, 2010
Sreekumar, J; Nandakumaran, V M(Physics Letters, October 21, 1985)
[+]
[-]
Abstract:
The phenomenon of two-soliton resonances of the Kadomtsev-Petviashvilli equation for the superfluid surface density fluctuation in He films is studied. The velocity of the resonant soliton is obtained.
Sreekumar, J; Nandakumaran, V M(Springer, December , 1989)
[+]
[-]
Abstract:
The dynamics of saturated two-dimensional superfluid4He films is shown to be governed by the Kadomtsev-Petviashvili equation with negative dispersion. It is established that the phenomena of soliton resonance could be observed in such films. Under the lowest order nonlinearity, such resonance would happen only if two dimensional effects are taken into account. The amplitude and velocity of the resonant soliton are obtained.
Sugunan, S(Indian Journal of Chemistry, February , 1983)
[+]
[-]
Abstract:
Solubilities of 4-nitrobenzoic acid at 25°, 35° and 42°C have
been determined in water and in the presence of several concentrations
of electrolytes. The free energies, enthalpies and entropies
of transfer are also reported. The data have been rationalized
by considering the structure-breaking effects of the ions of
the salts and the requirement of the localized hydrolysis model.
The theory of Symons is not satisfactory to rationalise the
experimental data.
Bindhu, C V; Harilal, S S; Nampoori, V P N; Vallabhan, C P G(World Scientific, 1999)
[+]
[-]
Abstract:
Dual beam thermal lens tecbnique is successfully employed for the determination of absolute
Fluorescence quantum yield of rhodamine 6G lnser dye in different solvents. A
532 nm radiation from a Q-switched Nd:YAG laser was used for the excitation purpose.
The fluorescence quantum yield values are found to be strongly influenced by environmental
effects. It has been observed that fluorescence yield is greater for rhodamine 6G
in ethylene glycol system than in water or in methanol. Our results also indicate that
parameters like concentration of the dye solution, aggregate formation and excited state
absorption affect the absolute values of fluorescence yield significantly.