Asha, K K; Dr. Devadasan, K(Central Institute of Fisheries Technology, 2010)
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Abstract:
Fulminant hepatic failure (FHF) is a dramatic and challenging syndrome in clinical medicine. Although an uncommon disorder, it is usually fatal and occurs in previously healthy person. While the causes of FHF remain unclear, viral hepatitis and drug-induced liver injury account for the majority of cases. Hepatitis E causes large-scale epidemics of hepatitis in the Indian subcontinent, involving hundreds of thousands of cases with high mortality. FHF is associated with several clinical features like jaundice, shrunken liver, easy bruising, low levels of serum proteins, fatigue, multi-organ failure etc and metabolic derangements like hypoglycemia, hyperlipidemia, hyponatremia, defective protein synthesis, reduced energy production, decreased rate of urea production etc. These disturbances are predominantly attributed to oxidative stress, membrane destabilization and osmolytic imbalances. The options available for these patients are quite minimal with liver transplantation being one of them. But the procedure is ridden with issues causing it to find less favor among the patients and the caregivers. Use of hepatoprotective and cytoprotective drugs, is being considered to be a more acceptable alternative as a strategy to enhance liver regeneration. In this regard use of taurine a naturally occurring amino acid that plays a crucial role in many physiological processes would prove to be effective. In the present study, hepatoprotective effect of taurine on a rat model of induced FHF was studied. Taurine supplementation has effectively counteracted the metabolic and structural aberrations in the liver caused by D-galactosamine intoxication.
Shiny, K S; Dr. Anandan, R(Cochin University of Science and Technology, February , 2007)
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Abstract:
The present study indicate that prior administration of
taurine is effective in minimizing all the deleterious effects induced by isoproterenol,
thereby justifying its use as a potent cytoprotective agent. The overall cardioprotective
effect of taurine is probably related to its antioxidant property evidenced by its ability to
reduce lipid peroxidation and to maintain the activities of free radical enzymes and nonenzymatic
antioxidants, its membrane stabilizing action and to its hypolipidemic property.
Description:
Dept.of Marine Biology,Microbiology and Biochemistry,Cochin University of Science and Technology
Mathew, K T; Robin, Augustine; Ullas G, Kalappura(Wiley InterScience, November , 2008)
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Abstract:
Hydroxyapatite (HAp, Ca10(PO4)6(OH)2) bioceramic and
chitosan (poly [( -1-4) D-glucosamine]) biopolymer show good biocompatibility
in vivo. They have biological origin and show excellent interactions
with microwave. Microwave study of HAp made using different
drying techniques and their composites with chitosan in the ISM band is
presented. Pastes are made using HAp and chitosan with different ratios
of mixing. The dielectric properties of this composites match with that of
human fat, collagen tissues. Some of the compositions exhibit dielectric
property close to that of natural bone. This makes them more
biocompatible and better substitutes for natural bone. Thus composite
bioceramics can be considered as phantom model constituents for
imaging purposes. Their dielectric properties prove that they are
biocompatible.
Chandramohanakumar, N; Josia, Jacob; Jayaraj, K A; Raveendran, T V; Balachandran, K K; Thresiamma, Joseph; Maheswari Nair; Achuthankutty, C T; K K C Nair; Rejomon, George; Zeena, P Ravi(Journal of Coastal research,West Palm Beach, Florida, May 23, 2007)
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Abstract:
Even though continental margins cover only about 7–9% of the world ocean area, they are important sites for organic
carbon accumulation and hence play a major role in biogeochemical carbon cycling. Surface sediments from the western
and eastern continental shelves of India were studied for their total organic matter content and the labile constituents
such as total carbohydrates and proteins to get a better understanding of the hydrological and biogeochemical
differences of the two regions on the nature of organic matter reaching the surface sediments. The sampling along
the west coast was done during September–October 2003, when upwelling signatures were found to be still persisting
along the shelf as evidenced by the low-oxygenated, nutrient-rich surface waters. The eastern shelf was sampled
during November–December 2002. The shelf was found to be oxygen saturated and oligotrophic during the season.
The surface sediments of the west coast contained a greater quantity of total organic matter when compared to the
east coast, but the percentages of labile constituents of total organic matter in the sediments were found to be higher
in the east coast by a factor of three as compared to the west coast. The differences in the productivity patterns and
the hydrographical conditions were found to exert a major influence on the quantity and composition of organic matter
in the surface sediments of the western and eastern continental shelves of India.
Rejo Mon George; K K C Nair(NATIONAL INSTITUTE OF OCEANOGRAPHY, November , 2005)
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Abstract:
The present study has been initiated to unravel the distribution of trace metals and its geochemical behavior in the Indian EEZ of the Arabian Sea and Bay of Bengal. Trace metal accumulation in aquatic consumers is of interest to ecologists and environmentalists so as to understand the fate and effect of contaminants in the food web dynamics and the biogeochemical cycling of trace metals. It is well established that oceanic distribution of macronutrients such as nitrate, phosphate and silicate provide critical to biological growth and related geochemical processes. In this study it can be inferred, that there is a need for a better understanding of background informations on trace metal concentrations with respect to space and time and their fluctuations in the Arabian Sea and Bay of Bengal zooplankton. Without a sound knowledge on spatio-temporal fluctuations, it will be impossible to differentiate anthropogenic metal inputs from natural background concentrations with a routine biomonitoring programme. Fe, Cu, Zn, Cd & Pb showed a slight enrichment in zooplankton from the Arabian Sea during spring intermonsoon compared to intermonsoon fall. The relative enrichment of Fe, Cu & Zn in zooplankton from the Arabian Sea during intermonsoon spring than intermonsoon fall was due to favourable bioaccumulation factors of these elements during this season. Nevertheless this study can be looked upon as a starting point for further investigations on these biogeochemically important processes, which are vital in addressing the dynamics of productivity of waters.
Budidaya menghasilkan sejumlah besar limbah, terdiri dari metabolisme oleh-produk, makanan sisa, materi
feses dan residu dari masukan profilaksis dan terapeutik, mengarah pada penurunan kualitas air dan wabah
penyakit. Bioremediasi, aplikasi mikroba / enzim untuk tambak, adalah metode yang sedang digunakan untuk meningkatkan kualitas air dan menjaga kesehatan
dan stabilitas sistem akuakultur. Bioremediasi melibatkan mineralisasi bahan organik menjadi karbon
dioksida, memaksimalkan produktivitas primer yang merangsang produksi udang, nitrifikasi dan denitrifikasi
untuk (1) menghilangkan kelebihan nitrogen dari tambak dan (2) mempertahankan beragam dan stabil
masyarakat kolam dimana patogen dikeluarkan dari sistem dan spesies diinginkan mendapatkan didirikan.
Selain dari bahan organik merendahkan (detritivorous) bakteri heterotrofik, nitrifikasi, bakteri denitrifikasi dan
fotosintesis umumnya digunakan dalam bioremediasi.
Joseph, P J; Dr. Ammini, Joseph(Cochin University of Science & Technology, April , 2007)
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Abstract:
The objective of this research is to study the feasibility of
bioremediating the oily sludge from a refinery site. Three different methods of
waste treatment were tried i.e. phytoremediation, land farming and microbial
enhanced oil separation in laboratory scale treatment systems. A multiprocess
approach by combination of phytoremediation, biostimulation and
microbial enhanced oil separation is also presented. The methods of analysis,
experimental procedure, and results are incorporated into five chapters of this
thesis entitled "Bioremediation of petroleum sludge through
phytoremediation, land farming and microbial enhanced oil separation.
Description:
School of Environmental Studies,
Cochin University of Science and Technology
A bivariate semi-Pareto distribution is introduced
and characterized using geometric minimization.
Autoregressive minification models for bivariate random
vectors with bivariate semi-Pareto and bivariate Pareto
distributions are also discussed. Multivariate
generalizations of the distributions and the processes are briefly indicated.
Rani, Joseph(HUthig & Wepf Verlag Basel, December 12, 1986)
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Abstract:
Blends of polychloroprene rubber and plasticized polyvinylchloride have been prepared
in various compositions and their properties evaluated. The properties of the
blends show that they can be used to replace polychloroprene in many applications
Nandhu, M S; Dr. Paulose, C S(Cochin University of Science and Technology, March , 2011)
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Abstract:
Parkinson's disease is a chronic progressive neurodegenerative movement
disorder characterized by a profound and selective loss of nigrostriatal dopaminergic
neurons. Our findings demonstrated that glutamatergic system is impaired during PD.
The evaluations of these damages have important implications in understanding the
molecular mechanism underlying motor, cognitive and memory deficits in PD. Our
results showed a significant increase of glutamate content in the brain regions of 6-
OHDA infused rat compared to control. This increased glutamate content caused an
increase in glutamatergic and NMDA receptors function. Glutamate receptor
subtypes- NMDAR1, NMDA2B and mGluR5 have differential regulatory role in
different brain regions during PD. The second messenger studies confirmed that the
changes in the receptor levels alter the IP3, cAMP and cGMP content. The alteration
in the second messengers level increased the expression of pro-apoptotic factors - Bax
and TNF-α, intercellular protein - α-synuclein and reduced the expression of
transcription factor - CREB. These neurofunctional variations are the key contributors
to motor and cognitive abnormalities associated with PD. Nestin and GFAP
expression study confirmed that 5-HT and GABA induced the differentiation and
proliferation of the BMC to neurons and glial cells in the SNpc of rats. We also
observed that activated astrocytes are playing a crucial role in the proliferation of
transplanted BMC which makes them significant for stem cell-based therapy. Our
molecular and behavioural results showed that 5-HT and GABA along with BMC
potentiates a restorative effect by reversing the alterations in glutamate receptor
binding, gene expression and behaviour abnormality that occur during PD. The
therapeutic significance in Parkinson’s disease is of prominence.
Description:
Department of Biotechnology, Cochin University of
Science and Technology